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  • Association of proton-pump inhibitor use with adverse health outcomes: A systematic umbrella review of meta-analyses of cohort studies and randomised controlled trials.

Association of proton-pump inhibitor use with adverse health outcomes: A systematic umbrella review of meta-analyses of cohort studies and randomised controlled trials.

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2022 Feb Systematic Review and Meta Analysis Fist_Author_Year_PM

Full Author : ['Veettil, Sajesh K', 'Sadoyu, Saranrat', 'Bald, Elizabeth M', 'Chandran, Viji P', 'Khuu, Scott Anh Tuan', 'Pitak, Panitan', 'Lee, Yeong Yeh', 'Nair, Athira Balakrishnan', 'Antony, Paul T', 'Ford, Alexander C', 'Chaiyakunapruk, Nathorn']
Journal Title : British journal of clinical pharmacology
Chapter : Section25
Journal Year : 2022

AIMS: The aim was to perform an umbrella review to summarise the existing evidence on proton-pump inhibitor (PPI) use and adverse outcomes and to grade the certainty of evidence. METHODS: Electronic databases were searched up to July 2021 for meta-analyses of cohort studies and/or randomised controlled trials (RCTs). Summary effect sizes from a random-effects model, between-study heterogeneity, 95% prediction interval, small-study effect, excess significance and credibility ceilings were devised to classify the credibility of evidence from meta-analyses of cohort studies, whereas the GRADE approach was used for meta-analyses of RCTs. RESULTS: In meta-analyses of cohort studies, 52 of the 91 examined associations were statistically significant (P

Keywords : ['systematic umbrella review', 'randomise control trial', 'protonpump inhibitor use', 'adverse health outcome', 'cohort study', 'metaanalyse', 'association']